Wheelsy is a small rural town where not much happens, but that is all going to change, and not for the better. Grant Grant, the town's wealthiest and most powerful citizen, is taking a walk through the woods when he comes across a strange and unfamiliar life form. Grant makes the mistake of getting too close and soon an alien creature invades his body. It is not long before Grant isn't the only one who has been attacked by the strange and slimy things. Grant's wife, Starla, begins to notice that something is very wrong with her husband. At the same time, Sheriff Bill Pardy becomes aware that there is a pattern of missing people and animals. Together, Starla and Bill set out to put a stop to the alien invaders intent upon taking over Wheelsy.
General Note
Originally released as a motion picture in 2006.
Special features: deleted scenes; extended scenes; gag reel; bringing the creatures to life; the sick minds and slimy days of Slither; set tour with Nathan Fillion; feature commentary with James Gunn and Nathan Fillion.