When Professor Pippy P. Poopypants comes to Jerome Horwitz Elementary School to teach science, and he goes off the deep end because students make fun of his name, only Captain Underpants can save the school from the professor's perilous plot.

Foreword: The Top-Secret Truth About Captain Underpants -- George and Harold -- All Hail New Swissland -- The Field Trip -- Left Behind -- The Fun Begins -- Bye Bye, Mr. Fyde -- Here, Oh Here -- The Sweetness and Innocence of Children -- The Gerbil Jogger 2000 -- Just One More Thing -- Captain Underpants and the Pied Pooper of Piqua -- Professor P. Goes Cra-Z -- Honey, I Shrunk the School -- The Perilous Plot -- The Name Change-O-Chart 2000 -- Fluffy and Cheeseball -- Captain Underpants to the Rescue -- Are You There, God? It's Us, Fluffy and Cheeseball -- The Flight of the Goofy Glider -- X-tra, X-tra, X-tra, X-tra, X-tra, X-tra, X-tra, X-tra, X-tra Large Underpants -- The Incredibly Graphic Violence Chapter (in Flip-O-Rama) -- The Twenty-Second Chapter -- To Make a Long Story Short -- The Chapter Before the Last Chapter -- The Chapter After the Chapter Before the Last Chapter --