Armed with the latest high-tech spy equipment, a covert government program of trained guinea pigs discover that the fate of the world is in their paws. Darwin is the squad leader determined to succeed at all costs; Blaster is an outrageous weapons expert with tons of attitude and a love for all things extreme; and Juarez, a sexy martial arts pro. Joining the group is Mooch, the literal fly-on-the-wall reconnaissance expert, and star-nosed mole Speckles, the computer and information specialist. The team takes on a mission for the U.S. government to stop the evil billionaire Leonard Saber who plans to destroy the world with household appliances. Before they can accomplish their mission, the government shuts them down and they are sentenced to a pet shop. There, they encounter a myriad of other members of the animal kingdom, including the lazy Hurley and hamster Bucky. They will escape the cage to defeat the villain, stop his threat, and save the world.

Based on a story by Hoyt H. Yeatman, Jr. & David P.I. James.